{"id":29,"date":"2025-09-26T11:30:00","date_gmt":"2025-09-26T09:30:00","guid":{"rendered":"https:\/\/egm.ibpc.fr\/?page_id=29"},"modified":"2026-10-20T18:22:39","modified_gmt":"2026-10-20T16:22:39","slug":"homepage","status":"publish","type":"page","link":"https:\/\/egm.ibpc.fr\/?page_id=29","title":{"rendered":"About EGM"},"content":{"rendered":"\n
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Microbial Gene Expression<\/h1>\n\n\n\n

From RNA biogenesis to translation and decay, deciphering microbial gene expression<\/p>\n\n\n\n

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Unit Director: Carine Tisn\u00e9

CNRS – UMR8261 \u23a5Universit\u00e9 Paris Cit\u00e9 \u23a5Institut de Biologie Physico-Chimique<\/p>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

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Our history<\/h2>\n\n\n\n

More than 60 years of research on microbial gene expression<\/h3>\n\n\n\n
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The roots of the Microbial Gene Expression unit (EGM)<\/strong> date back to 1959<\/strong>, when a laboratory dedicated to microbial gene expression was established at the Institut de Biologie Physico-Chimique (IBPC) by Marianne Grunberg-Manago<\/strong>, a pioneering figure in molecular biology. From its earliest years, the laboratory contributed to the emerging field of molecular genetics and to the understanding of the fundamental mechanisms controlling gene expression. Over the decades, RNA became a central theme of the unit\u2019s research<\/strong>, from its synthesis and maturation to its translation and degradation.<\/p>\n\n\n\n

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From gene expression to RNA biology<\/h3>\n\n\n\n

The scientific scope of EGM has progressively evolved alongside major advances in molecular biology.<\/p>\n\n\n\n

Research initially focused on fundamental mechanisms of transcription, translation and RNA metabolism in microorganisms<\/strong>. These themes subsequently expanded to include RNA processing and degradation, regulatory RNAs, RNA\u2013protein interactions, ribosome function, RNA modification and the structural mechanisms underlying RNA maturation.<\/p>\n\n\n\n

The unit has combined genetics, molecular biology and biochemistry<\/strong> throughout its history, while progressively integrating structural biology, genomics and high-throughput approaches.<\/p>\n\n\n\n

Different microbial model organisms have been used to address these questions, including Escherichia coli<\/em>, Bacillus subtilis<\/em>, Synechocystis<\/em> and Saccharomyces cerevisiae<\/em>. <\/p>\n\n\n\n

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An evolving research structure<\/h3>\n\n\n\n

The organization of the laboratory has changed over time while maintaining a strong scientific continuity.<\/p>\n\n\n\n

For a number of years, EGM operated as the CNRS UPR9073<\/strong> research unit. It subsequently evolved into the present UMR8261 \u2013 Expression G\u00e9n\u00e9tique Microbienne<\/strong>, jointly supported by the CNRS and Universit\u00e9 Paris Cit\u00e9<\/strong> without changing the unit\u2019s central objective: understanding how microorganisms control gene expression at the RNA and translation levels<\/strong>.<\/p>\n\n\n\n

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EGM today<\/h3>\n\n\n\n

Today, EGM brings together five scientifically autonomous research teams<\/strong> at the IBPC. <\/p>\n\n\n\n

Their research covers complementary aspects of RNA biology:<\/p>\n\n\n\n

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  • RNA maturation and decay<\/li>\n\n\n\n
  • RNA biogenesis, architecture and interactions<\/li>\n\n\n\n
  • RNA-mediated control of gene expression<\/li>\n\n\n\n
  • Physiology and regulation of protein synthesis<\/li>\n\n\n\n
  • Epitranscriptomic and translational responses to antibacterial stress<\/li>\n<\/ul>\n\n\n\n

    Together, these teams investigate how RNA is synthetized, processed, modified, translated and degraded<\/strong>, and how these processes allow microorganisms to regulate gene expression and adapt to changes in their environment.<\/p>\n\n\n\n

    The unit combines biochemical, genetic, molecular, structural and genome-wide approaches<\/strong> to investigate these mechanisms from the molecular to the cellular level. <\/p>\n<\/div><\/div>\n\n\n\n

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    Our history More than 60 years of research on microbial gene expression The roots of the Microbial Gene Expression unit (EGM) date back to 1959, when a laboratory dedicated to microbial gene expression was established at the Institut de Biologie Physico-Chimique (IBPC) by Marianne Grunberg-Manago, a pioneering figure in molecular biology. From its earliest years, the laboratory contributed to […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_front_end_style_editor":"no","ocean_post_layout":"full-width","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"footer-one","ocean_second_sidebar":"","ocean_disable_margins":"on","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"on","ocean_display_header":"off","ocean_header_style":"top","ocean_center_header_left_menu":"","ocean_custom_header_template":"","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"2","ocean_menu_typo_font_family":"","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"on","ocean_disable_heading":"enable","ocean_post_title":"","ocean_post_subheading":"CNRS - Universit\u00e9 Paris Cit\u00e9","ocean_post_title_style":"background-image","ocean_post_title_background_color":"","ocean_post_title_background":563,"ocean_post_title_bg_image_position":"center center","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"cover","ocean_post_title_height":200,"ocean_post_title_bg_overlay":0.1,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"on","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"on","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"","footnotes":""},"class_list":["post-29","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29"}],"version-history":[{"count":262,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":2048,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages\/29\/revisions\/2048"}],"wp:attachment":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}