{"id":34,"date":"2025-04-14T14:44:24","date_gmt":"2025-04-14T12:44:24","guid":{"rendered":"https:\/\/egm.ibpc.fr\/?page_id=34"},"modified":"2026-10-20T18:17:22","modified_gmt":"2026-10-20T16:17:22","slug":"rna-maturation-and-degradation","status":"publish","type":"page","link":"https:\/\/egm.ibpc.fr\/?page_id=34","title":{"rendered":"RNA maturation and decay"},"content":{"rendered":"\n
\"\"<\/span>
\n
\n

RNA Maturation And Decay (RNA MAD)<\/strong><\/p>\n\n\n\n

\n

How bacteria process and degrade RNA to adapt to changing environments and how yeast modify the translational apparatus. From molecular mechanisms to physiological roles in gene expression. <\/p>\n\n\n\n

<\/p>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n

Head <\/strong>: Ciar\u00e1n Condon<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

\n
\n
\"\"<\/figure>\n\n\n\n
\n

Model Organisms<\/strong>
Bacillus subtilis<\/em>, Saccharomyces cerevisiae<\/em><\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n

Key Methods<\/strong>
Biochemistry, genetics, molecular biology, high-throughput approches, structural biology<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n
\n

Main Topics<\/strong>
RNA processing and decay, Regulatory RNAs, Methylation of translation apparatus<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n
\n
\n

Research Focus<\/h1>\n\n\n\n

<\/p>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n
<\/div>\n<\/div>\n\n\n\n
<\/div>\n\n\n\n
\n
\n
\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
\n

Under the direction of Ciar\u00e1n Condon<\/strong> (DR1<\/strong>, CNRS<\/strong>), our team is interested in the identification, characterization and regulation of ribonucleases in Bacillus subtilis<\/em>. The team is currently working on the role and specificity of the KapD RNase involved in the sporulation process of B. Subtilis<\/em>.<\/p>\n\n\n\n

Fr\u00e9d\u00e9rique Braun (PU, Univ. Paris Cit\u00e9)<\/strong> is also characterizing a new RNase (Rae1\/YacP) that associates with the ribosome to cleave its target mRNAs.<\/p>\n\n\n\n

Sylvain Durand (CR, CNRS)<\/strong> investigates how regulatory RNAs control the expression of these RNases. More recently, his work has also focused on the role of RNase J2 within the RNase J1\/J2 complex.<\/p>\n\n\n\n

On the other hand, Val\u00e9rie Heurgu\u00e9-Hamard<\/strong> (DR2, CNRS<\/strong>) is interested in the methylation of the translational apparatus in the eukaryotic model organism Saccharomyces cerevisiae<\/em>. The major techniques used are molecular biology, genetics, protein biochemistry, as well as the determination of three-dimensional structures in collaboration with structural biologists.<\/p>\n<\/div>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n

Lab members<\/h1>\n\n\n\n

<\/p>\n\n\n\n

\n