{"id":34,"date":"2025-04-14T14:44:24","date_gmt":"2025-04-14T12:44:24","guid":{"rendered":"https:\/\/egm.ibpc.fr\/?page_id=34"},"modified":"2025-11-17T16:50:43","modified_gmt":"2025-11-17T14:50:43","slug":"rna-maturation-and-degradation","status":"publish","type":"page","link":"https:\/\/egm.ibpc.fr\/?page_id=34","title":{"rendered":"RNA maturation and decay"},"content":{"rendered":"\n
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Our Team<\/strong><\/h2>\n\n\n\n
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Under the direction of Ciar\u00e1n Condon<\/strong> (DR1<\/strong>, CNRS<\/strong>), our team is interested in the identification, characterization and regulation of ribonucleases in Bacillus subtilis<\/em>. The team is currently working on the role and specificity of the KapD RNase involved in the sporulation process of B. Subtilis<\/em>.<\/p>\n\n\n\n

Fr\u00e9d\u00e9rique Braun (MCU, Univ. Paris Cit\u00e9)<\/strong> is also characterizing a new RNase (Rae1\/YacP) that associates with the ribosome to cleave its target mRNAs.<\/p>\n\n\n\n

Sylvain Durand (CR, CNRS)<\/strong> investigates how regulatory RNAs control the expression of these RNases. More recently, his work has also focused on the role of RNase J2 within the RNase J1\/J2 complex.<\/p>\n\n\n\n

On the other hand, Val\u00e9rie Heurgu\u00e9-Hamard<\/strong> (DR2, CNRS<\/strong>) is interested in the methylation of the translational apparatus in the eukaryotic model organism Saccharomyces cerevisiae<\/em>. The major techniques used are molecular biology, genetics, protein biochemistry, as well as the determination of three-dimensional structures in collaboration with structural biologists.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

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Recent Publications<\/strong><\/h2>\n\n\n\n

Journal articles<\/p>

2025<\/p>

Valentin Deves, Alexandre D\u2019halluin, La\u00ebtitia Gilet, Ciar\u00e1n Condon, Fr\u00e9d\u00e9rique Braun. The endoribonuclease Rae1 from Bacillus subtilis cleaves mRNA upstream of stalled ribosomes. Nucleic Acids Research<\/i>, 2025, 53 (16), pp.gkaf843. ⟨10.1093\/nar\/gkaf843⟩<\/a>. ⟨hal-05384238⟩<\/a> \"PDF\"<\/a><\/dd><\/dl>
Mildred Delaleau, Vladimir Bidnenko, Eric Eveno, Gergana Kostova, Johnathan C Black, et al.. Comprehensive mapping of transcription terminator Rho utilization (Rut) sites across the Bacillus subtilis genome. Nucleic Acids Research<\/i>, 2025, 53 (15), ⟨10.1093\/nar\/gkaf765⟩<\/a>. ⟨hal-05229886⟩<\/a> \"PDF\"<\/a><\/dd><\/dl>
Armand Lablaine, Dimitri Juillot, Ciar\u00e1n Condon, Rut Carballido-L\u00f3pez. Real-time nanoscale investigation of spore coat assembly in Bacillus subtilis. Communications Biology<\/i>, 2025, 8 (1), pp.1131. ⟨10.1038\/s42003-025-08522-w⟩<\/a>. ⟨hal-05201355⟩<\/a> \"PDF\"<\/a><\/dd><\/dl>
La\u00ebtitia Gilet, Magali Leroy, Alexandre Maes, Ciaran Condon, Fr\u00e9d\u00e9rique Braun. Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis. FEBS Letters<\/i>, 2025, 599 (2025), pp.1222-1235. ⟨10.1002\/1873-3468.70027⟩<\/a>. ⟨hal-05386180⟩<\/a> \"PDF\"<\/a><\/dd><\/dl>
James C Taggart, Kathryn Julia Dierksheide, Hannah J Leblanc, Jean-Beno\u00eet Lalanne, Sylvain Durand, et al.. A high-resolution view of RNA endonuclease cleavage in Bacillus subtilis<\/i>. Nucleic Acids Research<\/i>, 2025, 53 (3), pp.gkaf030. ⟨10.1093\/nar\/gkaf030⟩<\/a>. ⟨hal-05384235⟩<\/a> \"PDF\"<\/a><\/dd><\/dl><\/div><\/em><\/p>\n\n\n\n

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Recent Publications<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":29,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"sidebar","ocean_second_sidebar":"","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"off","ocean_header_style":"","ocean_center_header_left_menu":"","ocean_custom_header_template":"","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"2","ocean_menu_typo_font_family":"","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"(Head: Ciar\u00e1n Condon)","ocean_post_title_style":"background-image","ocean_post_title_background_color":"","ocean_post_title_background":1021,"ocean_post_title_bg_image_position":"top center","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"cover","ocean_post_title_height":200,"ocean_post_title_bg_overlay":0.1,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"","footnotes":""},"class_list":["post-34","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages\/34","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34"}],"version-history":[{"count":159,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":1394,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages\/34\/revisions\/1394"}],"up":[{"embeddable":true,"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=\/wp\/v2\/pages\/29"}],"wp:attachment":[{"href":"https:\/\/egm.ibpc.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}