THE MICROBIAL GENE EXPRESSION UNIT
The unit was founded by Marianne Grunberg-Manago in the early 60s. We perform fundamental research on the control of gene expression in microorganisms (E. coli, B. subtilis, Synechocystis and S. cerevisiae) using genetic, biochemical and structural approaches. RNA, in all its forms, plays a central role in our work, which focuses on key steps in the control of gene expression: gene transcription, mRNA stability and translatability. The unit currently employs 35 people in 5 scientifically autonomous teams.
1 – RNA Maturation And Decay (Head: Ciarán Condon)
2 – Biogenesis, architecture and interactions of RNA (Head: Carine Tisné)
3 – RNA control of gene expression (Head: Maude Guillier)
4 – Physiology and regulation of protein synthesis (Head: Grégory Boël)
5 – Epitranscriptomic and translational responses to anti-bacterial Stress (Head: Zeynep Baharoglu)
NEWS
Carine Tisné has been awarded the CNRS Silver Medal for her work in RNA biochemistry
Carine Tisné explores the molecular intricacies of RNA, key molecules involved in gene expression and regulation. As CNRS research director at the Institut de Biologie Physico-Chimique (IBPC) in Paris, she develops and combines approaches in biochemistry, biophysics, and genetics to decode the maturation mechanisms that modify and activate RNA within cells. As expert in RNA structural biology, she has uncovered crucial maturation steps of mitochondrial transfer RNAs and ribosomal RNAs. Her fundamental research contributes to the rapidly growing field of epitranscriptomics, with implications ranging from better understanding of genetic diseases to identifying potential new cancer therapies. On a daily basis, Carine Tisné defends a resolutely collective and interdisciplinary approach to science, guided by an inalterable curiosity and a desire to help the projects and people around her grow.