Our Team
Under the direction of Ciarán Condon (DR1, CNRS), our team is interested in the identification, characterization and regulation of ribonucleases in Bacillus subtilis. The team is currently working on the role and specificity of the KapD RNase involved in the sporulation process of B. Subtilis.
Frédérique Braun (MCU, Univ. Paris Cité) is also characterizing a new RNase (Rae1/YacP) that associates with the ribosome to cleave its target mRNAs.
Sylvain Durand (CR, CNRS) investigates how regulatory RNAs control the expression of these RNases. More recently, his work has also focused on the role of RNase J2 within the RNase J1/J2 complex.
On the other hand, Valérie Heurgué-Hamard (DR2, CNRS) is interested in the methylation of the translational apparatus in the eukaryotic model organism Saccharomyces cerevisiae. The major techniques used are molecular biology, genetics, protein biochemistry, as well as the determination of three-dimensional structures in collaboration with structural biologists.
Recent Publications
Journal articles
2025
- Valentin Deves, Alexandre D’halluin, Laëtitia Gilet, Ciarán Condon, Frédérique Braun. The endoribonuclease Rae1 from Bacillus subtilis cleaves mRNA upstream of stalled ribosomes. Nucleic Acids Research, 2025, 53 (16), pp.gkaf843. ⟨10.1093/nar/gkaf843⟩. ⟨hal-05384238⟩
- Mildred Delaleau, Vladimir Bidnenko, Eric Eveno, Gergana Kostova, Johnathan C Black, et al.. Comprehensive mapping of transcription terminator Rho utilization (Rut) sites across the Bacillus subtilis genome. Nucleic Acids Research, 2025, 53 (15), ⟨10.1093/nar/gkaf765⟩. ⟨hal-05229886⟩
- Armand Lablaine, Dimitri Juillot, Ciarán Condon, Rut Carballido-López. Real-time nanoscale investigation of spore coat assembly in Bacillus subtilis. Communications Biology, 2025, 8 (1), pp.1131. ⟨10.1038/s42003-025-08522-w⟩. ⟨hal-05201355⟩
- Laëtitia Gilet, Magali Leroy, Alexandre Maes, Ciaran Condon, Frédérique Braun. Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis. FEBS Letters, 2025, 599 (2025), pp.1222-1235. ⟨10.1002/1873-3468.70027⟩. ⟨hal-05386180⟩
- James C Taggart, Kathryn Julia Dierksheide, Hannah J Leblanc, Jean-Benoît Lalanne, Sylvain Durand, et al.. A high-resolution view of RNA endonuclease cleavage in Bacillus subtilis. Nucleic Acids Research, 2025, 53 (3), pp.gkaf030. ⟨10.1093/nar/gkaf030⟩. ⟨hal-05384235⟩
