Publications

Journal articles

2025

Valentin Deves, Alexandre D’halluin, Laëtitia Gilet, Ciarán Condon, Frédérique Braun. The endoribonuclease Rae1 from Bacillus subtilis cleaves mRNA upstream of stalled ribosomes. Nucleic Acids Research, 2025, 53 (16), pp.gkaf843. ⟨10.1093/nar/gkaf843⟩. ⟨hal-05384238⟩

Mildred Delaleau, Vladimir Bidnenko, Eric Eveno, Gergana Kostova, Johnathan C Black, et al.. Comprehensive mapping of transcription terminator Rho utilization (Rut) sites across the Bacillus subtilis genome. Nucleic Acids Research, 2025, 53 (15), ⟨10.1093/nar/gkaf765⟩. ⟨hal-05229886⟩

Armand Lablaine, Dimitri Juillot, Ciarán Condon, Rut Carballido-López. Real-time nanoscale investigation of spore coat assembly in Bacillus subtilis. Communications Biology, 2025, 8 (1), pp.1131. ⟨10.1038/s42003-025-08522-w⟩. ⟨hal-05201355⟩

Laëtitia Gilet, Magali Leroy, Alexandre Maes, Ciaran Condon, Frédérique Braun. Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis. FEBS Letters, 2025, 599 (2025), pp.1222-1235. ⟨10.1002/1873-3468.70027⟩. ⟨hal-05386180⟩

James C Taggart, Kathryn Julia Dierksheide, Hannah J Leblanc, Jean-Benoît Lalanne, Sylvain Durand, et al.. A high-resolution view of RNA endonuclease cleavage in Bacillus subtilis. Nucleic Acids Research, 2025, 53 (3), pp.gkaf030. ⟨10.1093/nar/gkaf030⟩. ⟨hal-05384235⟩

2024

Corentin Baussier, Charlotte Oriol, Sylvain Durand, Béatrice Py, Pierre Mandin. Small RNA OxyS induces resistance to aminoglycosides during oxidative stress by controlling Fe-S cluster biogenesis in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 2024, ⟨10.1073/pnas.23178581211of10⟩. ⟨hal-04773313⟩

Vladimir Bidnenko, Arnaud Chastanet, Christine Péchoux, Yulia Redko-Hamel, Olivier Pellegrini, et al.. Complex sporulation-specific expression of transcription termination factor Rho highlights its involvement in Bacillus subtilis cell differentiation. Journal of Biological Chemistry, 2024, 300 (12), pp.107905. ⟨10.1016/j.jbc.2024.107905⟩. ⟨hal-04773401⟩

Alexandre Le Scornet, Ambre Jousselin, Kamila Baumas, Gergana Kostova, Sylvain Durand, et al.. Critical factors for precise and efficient RNA cleavage by RNase Y in Staphylococcus aureus. PLoS Genetics, 2024, 20 (8), pp.e1011349. ⟨10.1371/journal.pgen.1011349⟩. ⟨hal-04678641⟩

2023

Corentin Baussier, Charlotte Oriol, Sylvain Durand, Beatrice Py, Pierre Mandin. Small RNA regulation of an essential process induces bacterial resistance to aminoglycosides during oxidative stress. BioRxiv, 2023, ⟨10.1101/2023.10.13.562219⟩. ⟨hal-04250476⟩

Valentin Deves, Aude Trinquier, Laetitia Gilet, Jawad Alharake, Ciarán Condon, et al.. Shutdown of multidrug transporter bmrCD mRNA expression mediated by the ribosome-associated endoribonuclease (Rae1) cleavage in a new cryptic ORF. RNA, 2023, 29 (8), pp.1108-1116. ⟨10.1261/rna.079692.123⟩. ⟨hal-04279259⟩

Delphine Allouche, Gergana Kostova, Marion Hamon, Christophe H Marchand, Mathias Caron, et al.. New RoxS sRNA Targets Identified in Bacillus subtilis by Pulsed SILAC. Microbiology Spectrum, 2023, 11 (4), ⟨10.1128/spectrum.00471-23⟩. ⟨hal-04250461⟩

Aude Trinquier, Ciarán Condon, Frédérique Braun. Effect of tRNA Maturase Depletion on Levels and Stabilities of Ribosome Assembly Cofactor and Other mRNAs in Bacillus subtilis. Microbiology Spectrum, 2023, 11 (2), ⟨10.1128/spectrum.05134-22⟩. ⟨hal-04278788⟩

James Taggart, Jean-Benoit Lalanne, Sylvain Durand, Frédérique Braun, Ciarán Condon, et al.. A high-resolution view of RNA endonuclease cleavage in Bacillus subtilis. BioRxiv, 2023, ⟨10.1101/2023.03.12.532304⟩. ⟨hal-04250489⟩

2021

Sylvain Durand, Adam Callan-Sidat, Josie Mckeown, Stephen Li, Gergana Kostova, et al.. Identification of an RNA sponge that controls the RoxS riboregulator of central metabolism in Bacillus subtilis. Nucleic Acids Research, 2021, 49 (11), pp.6399 - 6419. ⟨10.1093/nar/gkab444⟩. ⟨hal-03404437⟩

Sylvain Durand, Maude Guillier. Transcriptional and Post-transcriptional Control of the Nitrate Respiration in Bacteria. Frontiers in Molecular Biosciences, 2021, 8, ⟨10.3389/fmolb.2021.667758⟩. ⟨hal-03404399⟩

Stephanie Oerum, Marjorie Catala, Maxime Bourguet, Laetitia Gilet, Pierre Barraud, et al.. Structural studies of RNase M5 reveal two-metal-ion supported two-step dsRNA cleavage for 5S rRNA maturation. RNA Biology, 2021, pp.1-11. ⟨10.1080/15476286.2021.1885896⟩. ⟨hal-03169718⟩

2020

Yiming Cai, Ben Usher, Claude Gutierrez, Anastasia Tolcan, Moise Mansour, et al.. A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems. Science Advances , 2020, 6 (31), pp.eabb6651. ⟨10.1126/sciadv.abb6651⟩. ⟨hal-04799068⟩

Stephanie Oerum, Tom Dendooven, Marjorie Catala, Laetitia Gilet, Clément Dégut, et al.. Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs. Molecular Cell, 2020, 80 (2), pp.227-236.e5. ⟨10.1016/j.molcel.2020.09.008⟩. ⟨hal-03015124⟩

Dmitriy Ignatov, Karolis Vaitkevicius, Sylvain Durand, Laty Cahoon, Stefanie Sandberg, et al.. An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes. Cell Reports, 2020, 30 (12), pp.4027-4040.e7. ⟨10.1016/j.celrep.2020.03.006⟩. ⟨hal-03004691⟩

Aude Trinquier, Sylvain Durand, Frédérique Braun, Ciarán Condon. Regulation of RNA processing and degradation in bacteria. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2020, 1863 (5), pp.194505. ⟨10.1016/j.bbagrm.2020.194505⟩. ⟨hal-03004764⟩

2019

Michaela Šiková, Jana Wiedermannová, Martin Převorovský, Ivan Barvík, Petra Sudzinová, et al.. The torpedo effect in Bacillus subtilis : RN ase J1 resolves stalled transcription complexes. EMBO Journal, 2019, 39 (3), ⟨10.15252/embj.2019102500⟩. ⟨hal-03013047⟩

Aude Trinquier, Jonathan E Ulmer, Laetitia Gilet, Sabine Figaro, Philippe Hammann, et al.. Transfer RNA Maturation Defects Lead to Inhibition of ribosomal RNA Processing via Synthesis of pppGpp. Molecular Cell, 2019, ⟨10.1016/j.molcel.2019.03.030⟩. ⟨hal-02104413⟩

2018

Kathrin Baumgardt, Laetitia Gilet, Sabine Figaro, Ciaran Condon. The essential nature of YqfG, a YbeY homologue required for 3′ maturation of Bacillus subtilis 16S ribosomal RNA is suppressed by deletion of RNase R. Nucleic Acids Research, 2018, 46 (16), pp.8605-8615. ⟨10.1093/nar/gky488⟩. ⟨hal-02349763⟩

2017

Laurent Sevaille, Laurent Gavara, Carine Bebrone, Filomena De luca, Lionel Nauton, et al.. 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 2017, 12 (12), pp.972-985. ⟨10.1002/cmdc.201700186⟩. ⟨hal-02923462⟩

Sylvain Durand, Frédérique Braun, Anne-Catherine Helfer, Pascale Romby, Ciaran Condon. sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation. eLife, 2017, 6, ⟨10.7554/eLife.23602⟩. ⟨hal-02171288⟩

Miao Ma, Ines Li de la sierra-Gallay, Noureddine Lazar, Olivier Pellegrini, Dominique Durand, et al.. The crystal structure of Trz1, the long form RNase Z from yeast. Nucleic Acids Research, 2017, ⟨10.1093/nar/gkx216⟩. ⟨hal-02390053⟩

Miao Ma, Ines Li de La Sierra Gallay, Noureddine Lazar, Olivier Pellegrini, Jean Lepault, et al.. Trz1, the long form RNase Z from yeast, forms a stable heterohexamer with endonuclease Nuc1 and mutarotase. Biochemical Journal, 2017, ⟨10.1042/BCJ20170435⟩. ⟨hal-02390058⟩

2016

Jeanne M. Dichiara, Bo Liu, Sabine Figaro, Ciarán Condon, David H. Bechhofer. Mapping of internal monophosphate 5 ends of Bacillus subtilis messenger RNAs and ribosomal RNAs in wild-type and ribonuclease-mutant strains. Nucleic Acids Research, 2016, 44 (7), pp.C. ⟨10.1093/nar/gkw073⟩. ⟨hal-01327381⟩

2015

Sylvain Durand, Arnaud Tomasini, Frédérique Braun, Ciarán Condon, Pascale Romby. sRNA and mRNA turnover in Gram-positive bacteria. FEMS Microbiology Reviews, 2015, 39 (3), pp.316-330. ⟨10.1093/femsre/fuv007⟩. ⟨hal-04865866⟩

Sylvain Durand, Frédérique Braun, Efthimia Lioliou, Cédric Romilly, Anne-Catherine Helfer, et al.. A nitric oxide regulated small RNA controls expression of genes involved in redox homeostasis in Bacillus subtilis. PLoS Genetics, 2015, 11 (2), ⟨10.1371/journal.pgen.1004957⟩. ⟨hal-02636652⟩

Frédérique Braun, Efthimia Lioliou, Cédric Romilly, Anne-Catherine Helfer, Laurianne Kuhn, et al.. A Nitric Oxide Regulated Small RNA Controls Expression of Genes Involved in Redox Homeostasis in Bacillus subtilis. PLoS Genetics, 2015, 11. ⟨hal-02329291⟩

2014

Bo Liu, Gintaras Deikus, Anna Bree, Sylvain Durand, Daniel B Kearns, et al.. Global analysis of mRNA decay intermediates in Bacillus subtilis wild-type and polynucleotide phosphorylase-deletion strains. Molecular Microbiology, 2014, 94 (1), pp.41-55. ⟨10.1111/mmi.12748⟩. ⟨hal-02328987⟩

2013

Sabine Figaro, Sylvain Durand, Laetitia Gilet, Nadège Cayet, Martin Sachse, et al.. Bacillus subtilis Mutants with Knockouts of the Genes Encoding Ribonucleases RNase Y and RNase J1 Are Viable, with Major Defects in Cell Morphology, Sporulation, and Competence. Journal of Bacteriology, 2013, 195 (10), pp.2340 - 2348. ⟨10.1128/jb.00164-13⟩. ⟨hal-04678866⟩

Jérémie Piton, Valéry Larue, Yann Thillier, Audrey Dorleans, Olivier Pellegrini, et al.. Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (22), pp.8858-8863. ⟨10.1073/pnas.1221510110⟩. ⟨hal-00829351⟩

2012

Sylvain Durand, Graziella Richard, François Bontems, Marc Uzan. Bacteriophage T4 polynucleotide kinase triggers degradation of mRNAs. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109, pp.7073 - 7078. ⟨10.1073/pnas.1119802109⟩. ⟨hal-04678851⟩

Sylvain Durand, Laetitia Gilet, Philippe Bessières, Pierre P. Nicolas, Ciaran Condon. Three essential ribonucleases-RNase y, J1, and III-control the abundance of a majority of bacillus subtilis mRNAs. PLoS Genetics, 2012, 8 (3), ⟨10.1371/journal.pgen.1002520⟩. ⟨hal-02646931⟩

Sylvain Durand, Laetitia Gilet, Ciarán Condon. The Essential Function of B. subtilis RNase III Is to Silence Foreign Toxin Genes. PLoS Genetics, 2012, 8 (12), pp.e1003181. ⟨10.1371/journal.pgen.1003181⟩. ⟨hal-04678860⟩

Sylvain Durand, Laetitia Gilet, Philippe Bessières, Pierre Nicolas, Ciarán Condon. Three Essential Ribonucleases—RNase Y, J1, and III—Control the Abundance of a Majority of Bacillus subtilis mRNAs. PLoS Genetics, 2012, 8 (3), pp.e1002520. ⟨10.1371/journal.pgen.1002520⟩. ⟨hal-04678841⟩

2011

Antonin Marchais, Sandra Duperrier, Sylvain Durand, Daniel Gautheret, Patrick Stragier. CsfG, a sporulation-specific, small non-coding RNA highly conserved in endospore formers. RNA Biology, 2011, 8, pp.358 - 364. ⟨10.4161/rna.8.3.14998⟩. ⟨hal-04678837⟩

Antonin Marchais, Sandra Duperrier, Sylvain Durand, Daniel Gautheret, Patrick Stragier. CsfG, a sporulation-specific, small non-coding RNA highly conserved in endospore formers.. RNA Biology, 2011, 8 (3), epub ahead of print. ⟨hal-00590918⟩

2010

Nathalie Mathy, Agnès Hébert, Peggy Mervelet, Lionel Benard, Audrey Dorleans, et al.. Bacillus subtilis ribonucleases J1 and J2 form a complex with altered enzyme behaviour. Molecular Microbiology, 2010, 75 (2), pp.489-498. ⟨10.1111/j.1365-2958.2009.07004.x⟩. ⟨hal-02923482⟩

Nathalie Mathy, Agnès M Hébert, Peggy Mervelet, Lionel Benard, Audrey Dorleans, et al.. Bacillus subtilis ribonucleases J1 and J2 form a complex with altered enzyme behaviour. Molecular Microbiology, 2010, 75 (2), pp.489-498. ⟨10.1111/j.1365-2958.2009.07004.x⟩. ⟨hal-03347836⟩

Sylvain Durand, Gisela Storz. Reprogramming of anaerobic metabolism by the FnrS small RNA. Molecular Microbiology, 2010, ⟨10.1111/j.1365-2958.2010.07044.x⟩. ⟨hal-04678833⟩

2009

Roula Daou-Chabo, Nathalie Mathy, Lionel Benard, Ciaran Condon. Ribosomes initiating translation of the hbs mRNA protect it from 5′-to-3′ exoribonucleolytic degradation by RNase J1. Molecular Microbiology, 2009, 71 (6), pp.1538-1550. ⟨10.1111/j.1365-2958.2009.06620.x⟩. ⟨hal-02923514⟩

Roula Daou-Chabo, Nathalie Mathy, Lionel Benard, Ciarán Condon. Ribosomes initiating translation of the hbs mRNA protect it from 5'-to-3' exoribonucleolytic degradation by RNase J1. Molecular Microbiology, 2009. ⟨hal-03347823⟩

Ming Fang, Wencke-Maria Zeisberg, Ciaran Condon, Vasily Ogryzko, Antoine Danchin, et al.. Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis.. Nucleic Acids Research, 2009, 37 (15), pp.5114-25. ⟨10.1093/nar/gkp527⟩. ⟨hal-00459936⟩

2007

Nathalie Mathy, Lionel Benard, Olivier Pellegrini, Roula Daou-Chabo, Wen Tingyi, et al.. 5′-to-3′ Exoribonuclease Activity in Bacteria: Role of RNase J1 in rRNA Maturation and 5′ Stability of mRNA. Cell Reports, 2007, 129 (4), pp.681-692. ⟨10.1016/j.cell.2007.02.051⟩. ⟨hal-03347782⟩

Robert Britton, Wen Tingyi, Laura Schaeffer, Olivier Pellegrini, William C Uiker, et al.. Maturation of the 5' end of Bacillus subtilis 16s rRNA by the essential ribonuclease YkqC/RNase J1. Molecular Microbiology, 2007, 63 (1), pp.127-138. ⟨10.1111/j.1365-2958.2006.05499.x⟩. ⟨hal-03347769⟩

2006

Sylvain Durand, Graziella Richard, Marco Bisaglia, Soumaya Laalami, François Bontems, et al.. Activation of RegB endoribonuclease by S1 ribosomal protein requires an 11 nt conserved sequence.. Nucleic Acids Research, 2006, 34 (22), pp.6549-6560. ⟨10.1093/nar/gkl911⟩. ⟨hal-00118229⟩

Benoît Odaert, Fakhri Saïda, Pascale Aliprandi, Sylvain Durand, Jean-Bernard Crechet, et al.. Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome.. Journal of Biological Chemistry, 2006, 282 (3), pp.2019-2028. ⟨10.1074/jbc.M608271200⟩. ⟨hal-00111728⟩

Inès Li de La Sierra-Gallay, Nathalie Mathy, Olivier Pellegrini, Ciarán Condon. Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA. Nature Structural and Molecular Biology, 2006, 13 (4), pp.376-377. ⟨10.1038/nsmb1066⟩. ⟨hal-03347756⟩

2005

Olivier Pellegrini, Nathalie Mathy, Arhonda Gogos, Lawrence Shapiro, Ciarán Condon. TheBacillus subtilis ydcDEoperon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Molecular Microbiology, 2005. ⟨hal-03347744⟩

Frédéric Allemand, Nathalie Mathy, Dominque Brechemier-Baey, Ciarán Condon. The 5S rRNA maturase, ribonuclease M5, is a Toprim domain family member. Nucleic Acids Research, 2005, 33 (13), pp.4368-4376. ⟨10.1093/nar/gki752⟩. ⟨hal-03347730⟩

2002

Christophe Merlin, Gregory Gardiner, Sylvain Durand, Millicent Masters. The Escherichia coli metD Locus Encodes an ABC Transporter Which Includes Abc (MetN), YaeE (MetI), and YaeC (MetQ). Journal of Bacteriology, 2002, 184, pp.5513 - 5517. ⟨10.1128/jb.184.19.5513-5517.2002⟩. ⟨hal-04678828⟩