Publications

Journal articles

2025

Louna Fruchard, Claudia Sudol, Caroline Rouard, Aurore Treffkorn-Maurau, Léo Hardy, et al.. Beyond RNA modification: a novel role for tRNA modifying enzyme in oxidative stress response and metabolism. Nucleic Acids Research, 2025, 53 (22), pp.gkaf1276. ⟨10.1093/nar/gkaf1276⟩. ⟨pasteur-05438616⟩

Léo Hardy, Virginie Marchand, Valérie Bourguignon, Quentin Thuillier, Cathy Dias, et al.. The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae. PLoS Genetics, 2025, 21 (10), pp.e1011937. ⟨10.1371/journal.pgen.1011937⟩. ⟨pasteur-05347080⟩

Louna Fruchard, Claudia Salinas, Andre Carvalho, Zeynep Baharoglu. tRNA-modifying enzymes in bacterial stress adaptation. Open Biology, 2025, 15 (10), pp.250194. ⟨10.1098/rsob.250194⟩. ⟨pasteur-05347156⟩

Manon Lang, Stéphane Renard, Imane El-Meouche, Ariane Amoura, Erick Denamur, et al.. Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters. Science Advances , 2025, 11 (36), pp.eadw7630. ⟨10.1126/sciadv.adw7630⟩. ⟨pasteur-05347101⟩

Louna Fruchard, Anamaria Babosan, Andre Carvalho, Manon Lang, Blaise Li, et al.. Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification. eLife, 2025, 13, pp.RP96317. ⟨10.7554/eLife.96317.3⟩. ⟨hal-05029047⟩

2024

Kevin Debatisse, Théophile Niault, Sarah Peeters, Amandine Maire, Busra Toktas, et al.. Fine-tuning of a CRISPRi screen in the seventh pandemic Vibrio cholerae. BMC Genomics, 2024, 25 (1), pp.985. ⟨10.1186/s12864-024-10891-1⟩. ⟨pasteur-05116026⟩

Lena Le Quellec, Andrey Aristov, Salomé Gutiérrez Ramos, Gabriel Amselem, Julia Bos, et al.. Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations. PLoS ONE, 2024, 19 (8), pp.e0303630. ⟨10.1371/journal.pone.0303630⟩. ⟨pasteur-04739933v2⟩

Sabrine Toubdji, Quentin Thullier, Lea-Marie Kilz, V. Marchand, Yifeng Yuan, et al.. Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (32), pp.e2401981121. ⟨10.1073/pnas.2401981121⟩. ⟨hal-04734945⟩

2023

Evelyne Krin, André Carvalho, Manon Lang, Anamaria Babosan, Didier Mazel, et al.. RavA‐ViaA antibiotic response is linked to Cpx and Zra2 envelope stress systems in Vibrio cholerae. Microbiology Spectrum, 2023, 11 (6), pp.e01730-23. ⟨10.1128/spectrum.01730-23⟩. ⟨pasteur-04260034⟩

Manon Lang, André Carvalho, Zeynep Baharoglu, Didier Mazel. Aminoglycoside uptake, stress, and potentiation in Gram-negative bacteria: new therapies with old molecules. Microbiology and Molecular Biology Reviews, 2023, ⟨10.1128/mmbr.00036-22⟩. ⟨pasteur-04334889⟩

Evelyne Krin, Zeynep Baharoglu, Odile Sismeiro, Hugo Varet, Jean-Yves Coppée, et al.. Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae. Research in Microbiology, 2023, 174 (1-2), pp.103997. ⟨10.1016/j.resmic.2022.103997⟩. ⟨pasteur-03889562⟩

2022

Anamaria Babosan, Louna Fruchard, Evelyne Krin, André Carvalho, Didier Mazel, et al.. Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress. microLife, 2022, 3, pp.uqac019. ⟨10.1093/femsml/uqac019⟩. ⟨pasteur-03897869v2⟩

Anamaria Babosan, David Skurnik, Anaëlle Muggeo, Gerald Pier, Zeynep Baharoglu, et al.. A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli. eLife, 2022, 11, ⟨10.7554/eLife.69511⟩. ⟨hal-03919325⟩

2021

André Carvalho, Evelyne Krin, Chloé Korlowski, Didier Mazel, Zeynep Baharoglu. Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in V. cholerae. Cells, 2021, 10 (11), pp.3227. ⟨10.3390/cells10113227⟩. ⟨pasteur-03443810v2⟩

André Carvalho, Didier Mazel, Zeynep Baharoglu. Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae. PLoS Genetics, 2021, 17 (10), pp.e1009748. ⟨10.1371/journal.pgen.1009748⟩. ⟨pasteur-03417428v2⟩

Manon Lang, Evelyne Krin, Chloé Korlowski, Odile Sismeiro, Hugo Varet, et al.. Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides. iScience, 2021, pp.103128. ⟨10.1016/j.isci.2021.103128⟩. ⟨pasteur-03349141⟩

2019

Veronica Negro, Evelyne Krin, Sebastian Aguilar Pierlé, Thibault Chaze, Quentin Giai Gianetto, et al.. RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin. mBio, 2019, 10 (4), pp.e01173-19. ⟨10.1128/mBio.01173-19⟩. ⟨pasteur-02171194⟩

2014

Zeynep Baharoglu, Didier Mazel. SOS, the formidable strategy of bacteria against aggressions. FEMS Microbiology Reviews, 2014, 38 (6), pp.1126-1145. ⟨10.1111/1574-6976.12077⟩. ⟨pasteur-01423593⟩

Zeynep Baharoglu, Didier Mazel. Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.. Research in Microbiology, 2014, 165 (6), pp.476-80. ⟨10.1016/j.resmic.2014.05.039⟩. ⟨pasteur-01423361⟩

Z. Baharoglu, A. Babosan, D. Mazel. Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.. Nucleic Acids Research, 2014, 42 (4), pp.2366-2379. ⟨10.1093/nar/gkt1259⟩. ⟨pasteur-01423602⟩

2013

Zeynep Baharoglu, Geneviève Garriss, Didier Mazel. Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance. Antibiotics, 2013, Antibiotic Resistance, 2 (2), pp.288-315. ⟨10.3390/antibiotics2020288⟩. ⟨pasteur-01691592⟩

Zeynep Baharoglu, Evelyne Krin, Didier Mazel. RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae. PLoS Genetics, 2013, 9 (4), pp.e1003421. ⟨10.1371/journal.pgen.1003421⟩. ⟨pasteur-01691109⟩

A. Gutierrez, L. Laureti, S. Crussard, H. Abida, A. Rodríguez-Rojas, et al.. β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity. Nature Communications, 2013, 4, pp.1610. ⟨10.1038/ncomms2607⟩. ⟨pasteur-01691736⟩

2012

Zeynep Baharoglu, Evelyne Krin, Didier Mazel. Connecting Environment and Genome Plasticity in the Characterization of Transformation-Induced SOS Regulation and Carbon Catabolite Control of the Vibrio cholerae Integron Integrase. Journal of Bacteriology, 2012, 194 (7), pp.1659-1667. ⟨10.1128/JB.05982-11⟩. ⟨pasteur-03941970⟩

2011

Zeynep Baharoglu, Didier Mazel. Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.. Antimicrobial Agents and Chemotherapy, 2011, 55 (5), pp.2438-2441. ⟨10.1128/AAC.01549-10⟩. ⟨pasteur-01423615⟩

2010

David Bikard, Céline Loot, Zeynep Baharoglu, Didier Mazel. Folded DNA in Action: Hairpin Formation and Biological Functions in Prokaryotes. Microbiology and Molecular Biology Reviews, 2010, 74 (4), pp.570-588. ⟨10.1128/MMBR.00026-10⟩. ⟨pasteur-02505407⟩

Zeynep Baharoglu, David Bikard, Didier Mazel. Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation. PLoS Genetics, 2010, 6 (10), pp.e1001165. ⟨10.1371/journal.pgen.1001165⟩. ⟨pasteur-02477623⟩

Zeynep Baharoglu, Roxane Lestini, Stéphane Duigou, Bénédicte Michel. RNA polymerase mutations that facilitate replication progression in the rep uvrD recF mutant lacking two accessory replicative helicases. Molecular Microbiology, 2010, 77 (2), pp.324. ⟨10.1111/j.1365-2958.2010.07208.x⟩. ⟨hal-00552639⟩

2007

Bénédicte Michel, Hasna Boubakri, Zeynep Baharoglu, Marie Lemasson, Roxane Lestini. Recombination proteins and rescue of arrested replication forks.. DNA Repair, 2007, 6 (7), pp.967-80. ⟨10.1016/j.dnarep.2007.02.016⟩. ⟨hal-00167418⟩

2006

Zeynep Baharoglu, Mirjana Petranovic, Maria-Jose Flores, Bénédicte Michel. RuvAB is essential for replication forks reversal in certain replication mutants.. EMBO Journal, 2006, 25 (3), pp.596-604. ⟨10.1038/sj.emboj.7600941⟩. ⟨hal-00130946⟩